![]() ![]() Given the lack of antibiotics specifically targeting sporulation, the prevalence of spore-forming pathogens in hospitals worldwide and existence of spore-forming pathogens that cause disease in pollinator insects (honey bees), understanding sporulation is important as a mean to provide a platform for translational opportunities controlling spore-forming bacteria. For this reason, spores are considered the vehicle of new and recurring infections in humans, animals and insects, and can contaminate food sources. Their dormant nature and resistance to these stressors allows them to persist in the environment for extended periods of time and when nutrients become available, spores emerge from dormancy to generate growing populations of bacteria. Importantly, spore resist stresses including: antibiotics, detergents, UV radiation and high temperatures. Furthermore, the various morphogenetic processes that underlie sporulation have made it a sophisticated model for understanding molecular mechanisms in bacterial biology. Its primordial nature has allowed it to serve as an excellent model system for understanding broadly relevant molecular aspects of cellular developmental. Spore development or sporulation is one of the earliest forms of cellular development on Earth and functions as a survival strategy against starvation. University of Registration: University of Warwick PhD project title: Spore formation in model and pathogenic bacteria Secondary supervisor: Associate Professor Meera Unnikrishan & Associate Professor Munehiro Asally Primary Supervisor: Associate Professor Christopher Rodrigues, School of Life Sciences ![]()
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